1-metyl-4-fenylpyridinium
1-metyl-4-fenylpyridinium (MPP+). En aktiv neurotoxisk metabolit av 1-metyl-4-fenyl-1,2,3,6-tetrahydropyridin (MPTP). Substansen sänker dopaminnivåer, hämmar katekolaminbiosyntesen, förbrukar kardiono repinefrin och inaktiverar tyrosinhydroxylas.Dessa och andra toxiska effekter leder till att oxidativ fosforilering upphör, till ATP-tömning och celldöd. Substansen, som är besläktad med paraquat, har också använts som ett växtgift.
Förklaring på engelska
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
Synonym, svenska:
Synonym, engelska: 1 Methyl 4 phenylpyridinium; 1-Methyl-4-phenylpyridine; 1 Methyl 4 phenylpyridine; N-Methyl-4-phenylpyridinium; N-Methyl-4-phenylpyridine; N Methyl 4 phenylpyridine; 1-Methyl-4-phenylpyridinium Ion; 1 Methyl 4 phenylpyridinium Ion; Cyperquat; 1-Methyl-4-phenylpyridinium Chloride; 1 Methyl 4 phenylpyridinium Chloride
| Svensk term | 1-metyl-4-fenylpyridinium |
| Synonym på svenska | |
| Synonym på engelska | 1 Methyl 4 phenylpyridinium; 1-Methyl-4-phenylpyridine; 1 Methyl 4 phenylpyridine; N-Methyl-4-phenylpyridinium; N-Methyl-4-phenylpyridine; N Methyl 4 phenylpyridine; 1-Methyl-4-phenylpyridinium Ion; 1 Methyl 4 phenylpyridinium Ion; Cyperquat; 1-Methyl-4-phenylpyridinium Chloride; 1 Methyl 4 phenylpyridinium Chloride |
| Engelsk term | 1-Methyl-4-phenylpyridinium |
| MESH ID | D015655 |