11-beta-hydroxisteroiddehydrogenas typ 2
Ett NAD-beroende 11-beta-hydroxysteroiddehydrogenas med hög affinitet som verkar enkelriktat för att katalysera dehydrogeneringen av KORTISOL till KORTISON. Det finns främst i mineralokortikoid målvävnader såsom NJURE; KOLON; SVETTKÖRTLAR; och placenta. Frånvaron av enzymet leder till en dödlig blankett [publikationstyp] av barndomshypertoni benämnd, UPPENBAR MINERALOCORTICOID EXCESS SYN
Förklaring på engelska
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
Synonym, svenska:
Synonym, engelska: 11 beta Hydroxysteroid Dehydrogenase Type 2; 11beta-Hydroxysteroid Dehydrogenase Type 2; 11beta Hydroxysteroid Dehydrogenase Type 2; 11beta-HSD2; 11beta-HSD2 Reductase; 11 beta-HSD2; 11 beta-Hydroxysteroid Dehydrogenase Type 2
| Svensk term | 11-beta-hydroxisteroiddehydrogenas typ 2 |
| Synonym på svenska | |
| Synonym på engelska | 11 beta Hydroxysteroid Dehydrogenase Type 2; 11beta-Hydroxysteroid Dehydrogenase Type 2; 11beta Hydroxysteroid Dehydrogenase Type 2; 11beta-HSD2; 11beta-HSD2 Reductase; 11 beta-HSD2; 11 beta-Hydroxysteroid Dehydrogenase Type 2 |
| Engelsk term | 11-beta-Hydroxysteroid Dehydrogenase Type 2 |
| MESH ID | D043209 |