Cytokrom P-450 CYP2D6
Ett polymorft enzym som katalyserar hydroxyleringen av debrisokin. Det omsätter också ett flertal antidepressiva och neuroleptiska preparat. Enzymet uppvisar defekter hos ungefär 10% av befolkningen. EC 1.14.99.-.
Förklaring på engelska
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.
Synonym, svenska:
Synonym, engelska: CYP2D6, Cytochrome P-450; Cytochrome P 450 CYP2D6; P-450 CYP2D6, Cytochrome; Sparteine Monooxygenase; Monooxygenase, Sparteine; Cytochrome P450 2D6; P450 2D6, Cytochrome; Debrisoquine 4-Monooxygenase; 4-Monooxygenase, Debrisoquine; Debrisoquine 4 Monooxygenase; Imipramine 2-Hydroxylase; 2-Hydroxylase, Imipramine; Imipramine 2 Hydroxylase; CYP2D6; CYP 2D6; Debrisoquine 4-Hydroxylase; 4-Hydroxylase, Debrisoquine; Debrisoquine 4 Hydroxylase; Debrisoquine Hydroxylase; Hydroxylase, Debrisoquine
| Svensk term | Cytokrom P-450 CYP2D6 |
| Synonym på svenska | |
| Synonym på engelska | CYP2D6, Cytochrome P-450; Cytochrome P 450 CYP2D6; P-450 CYP2D6, Cytochrome; Sparteine Monooxygenase; Monooxygenase, Sparteine; Cytochrome P450 2D6; P450 2D6, Cytochrome; Debrisoquine 4-Monooxygenase; 4-Monooxygenase, Debrisoquine; Debrisoquine 4 Monooxygenase; Imipramine 2-Hydroxylase; 2-Hydroxylase, Imipramine; Imipramine 2 Hydroxylase; CYP2D6; CYP 2D6; Debrisoquine 4-Hydroxylase; 4-Hydroxylase, Debrisoquine; Debrisoquine 4 Hydroxylase; Debrisoquine Hydroxylase; Hydroxylase, Debrisoquine |
| Engelsk term | Cytochrome P-450 CYP2D6 |
| MESH ID | D019389 |