Cytokrom P-450 CYP2E1
Ett polymorft enzym som aktiverar cancerframkallande N-nitrosaminer, bensen, uretan och andra föreningar med låg molekylvikt. Det induceras av etanol och metaboliserar alkohol. Det används experimentellt för att studera effekterna av etanolbruk och -abstinens med hjälp av enzymmarkörer som t ex N-nitrosodimetylamindemetylas. EC 1.5.99.-.
Förklaring på engelska
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
Synonym, svenska:
Synonym, engelska: Cytochrome P 450 CYP2E1; Cytochrome P-450-J; Cytochrome P 450 J; 4-Nitrophenol-2-Hydroxylase; 4 Nitrophenol 2 Hydroxylase; Dimethylnitrosamine N-Demethylase; Dimethylnitrosamine N Demethylase; Cytochrome P450 2E1; N-Nitrosodimethylamine Demethylase; N Nitrosodimethylamine Demethylase; CYP 2E1; Cytochrome P-450 IIE1; Cytochrome P 450 IIE1; CYP IIE1; CYPIIE1; Cytochrome P-450 (ALC); CYP2E1
| Svensk term | Cytokrom P-450 CYP2E1 |
| Synonym på svenska | |
| Synonym på engelska | Cytochrome P 450 CYP2E1; Cytochrome P-450-J; Cytochrome P 450 J; 4-Nitrophenol-2-Hydroxylase; 4 Nitrophenol 2 Hydroxylase; Dimethylnitrosamine N-Demethylase; Dimethylnitrosamine N Demethylase; Cytochrome P450 2E1; N-Nitrosodimethylamine Demethylase; N Nitrosodimethylamine Demethylase; CYP 2E1; Cytochrome P-450 IIE1; Cytochrome P 450 IIE1; CYP IIE1; CYPIIE1; Cytochrome P-450 (ALC); CYP2E1 |
| Engelsk term | Cytochrome P-450 CYP2E1 |
| MESH ID | D019392 |