Enkelsträngad konformationell polymorfism
Variation i en populations DNA-sekvens som detekteras genom bestämning av förändringar i konformationen av denaturerade DNA-fragment. Denaturerade DNA-fragment får renaturera under förhållanden som förhindrar bildandet av dubbelsträngat DNA och tillåter sekundär struktur att blankett [publikationstyp] i enkelsträngade fragment. Dessa fragment körs sedan genom polyakrylamidgeler för att detektera variationer i den sekundära strukturen som manifesteras som en förändring i migration genom geler.
Förklaring på engelska
Variation in a population’s DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
Synonym, svenska: SSCP
Synonym, engelska: Polymorphism, Single Stranded Conformational; SSCP; Single-Stranded Conformational Polymorphism; Conformational Polymorphism, Single-Stranded; Conformational Polymorphisms, Single-Stranded; Polymorphisms, Single-Stranded Conformational; Single Stranded Conformational Polymorphism; Single-Stranded Conformational Polymorphisms
| Svensk term | Enkelsträngad konformationell polymorfism |
| Synonym på svenska | SSCP |
| Synonym på engelska | Polymorphism, Single Stranded Conformational; SSCP; Single-Stranded Conformational Polymorphism; Conformational Polymorphism, Single-Stranded; Conformational Polymorphisms, Single-Stranded; Polymorphisms, Single-Stranded Conformational; Single Stranded Conformational Polymorphism; Single-Stranded Conformational Polymorphisms |
| Engelsk term | Single-stranded conformational polymorphism |
| MESH ID | D018807 |